Powerkid follows Rash’s journey as he’s recruited into an elite assassination organization alongside other children, each possessing extraordinary abilities. After saving a high-ranking agent and losing his memories in the process, the organization is deeply indebted to him and thrusts him into their rigorous training program. He possesses a remarkable regenerative ability, but when his eyes blaze crimson, his healing accelerates, and he’s also granted an unsettling boon.

Driven to become one of the organization's greatest assassins, Rash hopes to one day leverage that position to uncover the truth of his mysterious and forgotten past. He’ll be partnered with Emilia, whose confrontational personality proved too disruptive for her previous division, and Chizaru, a stoic monk who can ignite himself in flames, a stark contrast to his peaceful nature. Each carries their own burdens: Rash seeks answers to his past, Emilia navigates a precarious existence within the organization, and Chizaru walks a shadowed path to protect his village.

As part of the new Powerkid Project within the organization, Rash, Emilia, and Chizaru face formidable challenges: rival agencies, dangerous cults, and targets with extraordinary powers. But can he truly trust those around him as he searches for the truth? And what secrets lie hidden within the walls of the organization?